Regeneration is itself somewhat risky and very unpleasant, so healing injuries is still much preferred over simply getting a new body and starting over, unless the body is near the end of its time anyway.

After a regeneration, it's common to experience post-regenerative trauma. One's mind and body are suddenly unfamiliar ground and still in flux, still taking shape. It's extremely disorienting and those who have recently regenerated can be highly susceptible to outside influences.

Regenerations can also sometimes fail, although it's very rare for that to happen. When it does people can end up split between bodies, or mutated, or temporally fractured.